Topics identified by participant survey responses and faculty recommendations
Developed independently by expert faculty from the most current available studies
The European School of Haematology (ESH) is pleased to present this free online educational tool for haematologists and other clinicians involved in the care of patients with iron metabolism disorders.
This high-level comprehensive Programme features the very latest information about iron metabolism and the management of related disorders in four distinctive, progressive curricula which build upon each other, and are designed to help you provide state-of-the-science treatment to improve your patients' outcomes.
Ask the Experts We welcome your questions, comments, and suggestions as one critical way to continuously improve the activities we offer.
released May 2010
Co-Chairs:
Photis Beris, MD
Professor of Haematology
Chairman of the Department
of Haematology
National and Kapodistrian
University of Athens
School of Medicine
Laiko University Hospital
Athens, Greece
Pierre Brissot, MD
Professor of Medicine
Liver Disease Department
University Hospital
Pontchaillou
Rennes, France
Maria D. Cappellini, MD
Professor of Internal
Medicine
University of Milan
Maggiore Hospital
Milan, Italy
Programme Overview
Iron Metabolism
Molecular physiology of iron metabolism
Factors contributing to iron pathophysiology
Role of hepcidin, ferroportin, transferrin, NTBI, LPI in iron metabolism
Brief overview of spectrum of chronic overload diseases
Transfusional iron overload
Myelodysplastic syndromes (MDS)
Sickle cell disease (SCD)
Thalassaemia
Other transfusional anaemias
Genetic iron overload
Hereditary haemochromatosis (classic)
Juvenile haemochromatosis
Brief overview of visceral targets of iron excess
Heart
Liver
Endocrine system (including diabetes)
Musculoskeletal system
Epidemiology and Disease Pathophysiology
Myelodysplastic syndromes (MDS)
MDS epidemiology
MDS pathophysiology
MDS diagnosis and management
Thalassaemia
Thalassaemia epidemiology
Thalassaemia pathophysiology
Thalassaemia diagnosis and management
Sickle cell disease (SCD)
SCD epidemiology
SCD pathophysiology
SCD diagnosis and management
Other anaemias
Epidemiology of other anaemias
Pathophysiology of other anaemias
Diagnosis and management of other anaemias
Hereditary Haemochromatosis
HH epidemiology
HH pathophysiology
HH diagnosis and management
Iron Deficiency
Epidemiology of iron deficiency
Pathophysiology of iron deficiency
Clinical sequelae of iron deficiency
Diagnosis and management of iron deficiency
Iron Toxicity and Clinical Sequelae
Molecular basis of iron overload
Causes of iron overload
Primary causes of iron overload (hereditary)
Hereditary haemochromatosis (classic)
Juvenile haemochromatosis
African iron overload
Secondary causes of iron overload (transfusional)
Myelodysplastic syndromes (MDS)
Sickle cell disease (SCD)
Thalassaemia
Other transfusional anaemias
Clinical sequelae of iron overload
Heart
Microscopic consequences of iron overload in the heart
Functional consequences of iron overload in the heart
Liver
Microscopic consequences of iron overload in the liver
Functional consequences of iron overload in the liver
Endocrine system (including diabetes)
Microscopic consequences of iron overload in the endocrine system
Functional consequences of iron overload in the endocrine system
Musculoskeletal system
Microscopic consequences of iron overload in the musculoskeletal system
Functional consequences of iron overload in the musculoskeletal system
Link to cancer
HCC, esophageal and intestinal cancer, melanoma, and lung cancer
Others
Morbidity and mortality associated with iron overload/toxicities
Diagnosis of Iron Overload
Methodologies for diagnosing and monitoring iron overload
Established methodologies
Liver biopsy - invasive, direct measurement
Review of methodology
Review of factors affecting the accuracy of liver biopsy measurements
