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Curriculum
Activity Information
Target Audience
Learning Objectives
Technical Requirements
The Curriculum in Iron Metabolism & Related Disorders is supported by an educational grant from
Projects In Knowledge is a registered trademark of Projects In Knowledge, Inc.
Course materials have been developed for use outside of the United States.
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Epidemiology and Disease Pathophysiology:
Sickle Cell Disease
“Sickle Cell Disease: A Short Guide to Management,” chapter 13 from the European School of Haematology - Club du Globule Rouge et du Fer Handbook on Disorders of Iron Homeostasis, Erythrocytes and Erythropoiesis (2006), is reprinted here with permission. We wish to acknowledge and thank the ESH; handbook editors Carole Beaumont, Photis Béris, Yves Beuzard, and Carlo Brugnara; chapter 13 author Frédéric Galactéros; and Novartis Oncology, Vifor International, and Amgen Inc, which have provided educational grants in support of this handbook.
Chapter 13 Table of Contents
| Topic |
|
Page |
1. |
Introduction |
277 |
2. |
Pathophysiology and Modifying Factors |
278 |
| 3. |
General Health Management |
282 |
| 4. |
Anaemia and Principles of Transfusion |
284 |
| 5. |
Acute Painful Episodes |
287 |
| 6. |
Chronic Painful Complications |
291 |
| 7. |
Sickle Cell Vascular Diseases |
293 |
| 8. |
Organ Insufficiencies |
296 |
| 9. |
Other Common Problems |
298 |
| 10. |
Major Preventive and Curative Treatments |
299 |
| 11. |
Conclusions |
301 |
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References |
301 |
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Target Audience
This activity is designed for haematologists, medical oncologists, haematology-oncology specialists, and other healthcare professionals involved in the screening, evaluation, treatment, and management of adults and children with iron overload, resulting from the spectrum of chronic iron overload diseases. |
Learning Objectives
After participating in this activity, participants should be better able to:
- Based on knowledge of the pathophysiology of SCD and current treatment recommendations, institute appropriate treatment strategies to prevent/treat acute complications of SCD including vaso-occlusion, acute chest syndrome, priapism, and acute abdominal pain.
- Based on an understanding of the factors that may provoke vaso-occlusion, counsel your patients with SCD about the things that they should avoid in order to prevent/reduce these occurrences.
- Apply your knowledge of the risks of iron overload in patients with SCD to prevent, identify, and treat this event.
- Utilize knowledge of the risks and signs/symptoms of sickle cell vascular diseases, including retinal impairment, acute auditory loss, cerebral vasculopathy, and pulmonary vascular disease, to identify and treat affected patients.
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