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Activity Information
Target Audience
Learning Objectives
Technical Requirements
The Curriculum in Iron Metabolism & Related Disorders is supported by an educational grant from
Projects In Knowledge is a registered trademark of Projects In Knowledge, Inc.
Course materials have been developed for use outside of the United States.
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Iron Toxicity and Clinical Sequelae II
In this 30-minute interview, Dr. Maria Cappellini is joined by three experts in iron toxicity—Dr. John Wood, Prof. Antonello Pietrangelo, and Dr. Ratna Chatterjee—to discuss the effects of iron overload on the heart, liver, and endocrine system, with a particular focus on the impact of iron toxicity on fertility and pregnancy. In addition, they explore the potential for preventing/reversing these damaging effects with iron chelation therapy.
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Chair
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Maria D. Cappellini, MD
Professor of Internal
Medicine
University of Milan
Chief, Hereditary Anaemia
Centre
Maggiore Hospital
Milan, Italy
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Faculty
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Ratna Chatterjee, MD, PhD
Senior Lecturer
Honorary Consultant in
Chronic Serious Disease
Department of Obstetrics
and Gynaecology
University College London
London, United Kingdom
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Antonello Pietrangelo, MD, PhD
Professor of Internal
Medicine
Department of Internal
Medicine
University of Modena and
Reggio Emilia
Modena Italy
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John C. Wood, MD, PhD
Assistant Professor
Keck School of Medicine of
USC
Division of Cardiology
Childrens Hospital
Los Angeles
Los Angeles, California
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Target Audience
This activity is designed for haematologists, medical oncologists, haematology-oncology specialists, and other healthcare professionals involved in the screening, evaluation, treatment, and management of adults and children with iron overload, resulting from the spectrum of chronic iron overload diseases.
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Learning Objectives
After participating in this activity, participants should be better able to:
- Apply an understanding of the effects of iron toxicity at the cellular and organ level, the clinical/laboratory signs of iron overload, and the risk factors for iron toxicity on the heart, liver, and endocrine system to identify transfusion-dependent patients at risk of damage from iron toxicity.
- Based on the diagnostic criteria for iron chelation therapy in patients with transfusion-dependent anaemia, institute chelation therapy to reduce iron overload and prevent/reverse the effects of iron toxicity on the heart, liver, and endocrine system.
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Disclosure Information
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Maria D. Cappellini, MD, is a consultant for and on the speakers bureau of Novartis Pharmaceuticals Corporation. Prof. Cappellini has disclosed that she will not reference any unlabeled/unapproved uses of drugs or devices.
Ratna Chatterjee, MD, PhD, has no significant relationships to disclose. Dr. Chatterjee has disclosed that she will not reference any unlabeled/unapproved uses of drugs or devices.
Antonello Pietrangelo, MD, PhD, has no significant relationships to disclose. Dr. Pietrangelo has disclosed that she will not reference any unlabeled/unapproved uses of drugs or devices.
John C. Wood, MD, PhD, has received grant/research support from, is on the speakers bureau of, and is on the advisory board for Novartis Pharmaceuticals Corporation; and is on the advisory board for Apotex Inc. Dr. Wood has disclosed that she will not reference any unlabeled/unapproved uses of drugs or devices.
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