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The Curriculum in Iron Metabolism & Related Disorders is supported by an educational grant from
Novartis Oncology

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Iron Overload Case Library, Case 3: Dose Titration in a Paediatric Patient with Sickle Cell Disease


To prevent neurologic complications, 10% of children with sickle cell disease begin monthly transfusions at a young age. This paediatric sickle cell disease case illustrates the iron overload that can occur in young sickle cell patients, and provides an example of the need for knowledgeable dosage titration and adjustments in decreasing serum ferritin levels and managing side effects.
Faculty
Mariane de Montalembert, MD
Mariane de Montalembert, MD
Service de Pédiatrie
Hospital Necker
Paris, France

Target Audience

This activity is designed for haematologists, medical oncologists, haematology-oncology specialists, and other healthcare professionals involved in the screening, evaluation, treatment, and management of adults and children with iron overload, resulting from the spectrum of chronic iron overload diseases.

Learning Objectives


After participating in this activity, participants should be better able to:
  • Utilize appropriate dose and dosage adjustments to improve suboptimal response to iron chelation therapy and manage side effects in transfused paediatric patients with sickle cell disease.
Disclosure Information

Mariane de Montalembert, MD, is on the advisory board for Novartis Pharmaceuticals Corporation. Dr. de Montalembert has disclosed that she will not reference any unlabeled/unapproved uses of drugs or devices.

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